As part of an ongoing study of carpal tunnel syndrome (CTS) in industry, we measured plasma concentrations of pyridoxal 5'-phosphate (PLP, a measure of vitamin B6 status) and total ascorbate (ASC, a measure of vitamin C status) in 441 adult volunteers from six industries and a university exercise study.
In the entire study group and in non-vitamin users (n=218), there were no significant differences in mean plasma PLP or ASC concentrations between controls (neither symptoms nor slowing), subjects with symptoms only, subjects with median nerve slowing only, or subjects with CTS (symptoms+slowing).
In male non-vitamin users (n=137), there were significant inverse univariate associations between plasma PLP concentration and the prevalence of pain, the frequency of tingling and nocturnal awakening, and the Phalen test result.
In this same subgroup, the ASC/PLP ratio was directly associated with the prevalence of pain and nocturnal awakening and with the frequency of pain, tingling, and nocturnal awakening.
In multivariate analyses, plasma ASC concentration predicted more median nerve slowing and confirmed CTS, and vitamin or vitamin interaction variables were independent predictors of 20 CTS-related outcomes.
These multivariate relationships often occurred only after adjustment for age, gender, body mass index, serum alkaline phosphatase activity, or tobacco use. (...)
Mots-clés Pascal : Canal carpien syndrome, Epidémiologie, Etat nutritionnel, Pyridoxine, Acide ascorbique, Vitamine, Homme, Compression, Système nerveux pathologie, Nerf périphérique pathologie, Système ostéoarticulaire pathologie
Mots-clés Pascal anglais : Carpal tunnel syndrome, Epidemiology, Nutritional status, Pyridoxine, Ascorbic acid, Vitamin, Human, Compression, Nervous system diseases, Peripheral nerve disease, Diseases of the osteoarticular system
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0541111
Code Inist : 002B17A08. Création : 24/03/1998.