Objectives Blood-lead levels (B-Pb), and to some extent urinary lead (U-Pb), are the most employed measures of lead exposure and risk.
However, the small fraction of lead present in plasma (usually below 1% of that in blood) is probably more relevant to lead exposure and toxicity.
Nevertheless, the lead content of plasma lead (P-Pb) has only seldom been used, mainly due to analytical limitations, which have now been overcome.
We examined P-Pb in occupationally exposed subjects, as well as its relationship with B-Pb and U-Pb.
Methods Blood samples were obtained from 145 male workers, 110 of whom were employed in lead work.
After a simple dilution of plasma, P-Pb was determined by inductively coupled plasma mass spectrometry.
The detection limit was 0.04 mug/l, and the imprecision was 5%. Results The lead concentration ranges were 0.20-37 mug/l for P-Pb, 0.9-176 mug/l (density adjusted) for U-Pb, and 9-930 mug/l for B-Pb.
A close exponential relation was obtained between B-Pb and P-Pb.
When B-Pb was plotted versus log P-Pb, a straight line (log P-Pb=0.00225.
B-Pb - 0.58 ; r=0.97) was obtained.
Both the relation between U-Pb and P-Pb and that between U-Pb and B-Pb showed a large scattering (r=0.78 in both cases).
The relation to B-Pb appeared to be exponential, while that to P-Pb appeared to be linear.
Conclusions The low detection limit and good precision of P-Pb determinations make it possible to use P-Pb in assessments of lead exposure and risk. (...)
Mots-clés Pascal : Plomb, Métal lourd, Taux, Liquide biologique, Urine, Plasma sanguin, Sang, Analyse quantitative, Spectrométrie ICP, Surveillance biologique, Exposition professionnelle, Médecine travail, Homme
Mots-clés Pascal anglais : Lead, Heavy metal, Rate, Biological fluid, Urine, Blood plasma, Blood, Quantitative analysis, Inductive coupling plasma spectrometry, Biological monitoring, Occupational exposure, Occupational medicine, Human
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0539699
Code Inist : 002B03L05. Création : 24/03/1998.