A cross sectional assessment of health status instruments in patients with rheumatoid arthritis participating in a clinical trial.
To (1) validate the Short-Form Health Survey (SF-36) as a generic functional health status measure in patients with rheumatoid arthritis (RA) : and (2) assess correlations between the SF-36 and other outcome measures used in the Minocycline in Rheumatoid Arthritis (MIRA) Trial.
We conducted a cross sectional analysis of the final visit outcome measures from the 48 week, multicenter, placebo controlled, double blind MIRA trial.
Multitrait scaling analyses assessed convergent and discriminant validity and internal consistency reliability of the SF-36 in the study patients.
Responses to comparable items on the SF-36 and modified Health Assessment Questionnaire (M-HAQ) regarding physical functioning were compared and questions from both instruments were also compared to other RA outcome measures.
In patients with RA, the SF-36 had high internal consistency and reliability, high discriminant and high convergent validity.
Moderate correlations were observed (r=-0.46 to - 0,61, p<0.01 in each case) for comparable items on the SF-36 and M-HAQ regarding dressing, walking, and bending.
Joint tenderness score correlations with items on the M-HAQ and SF-36, and joint tenderness score correlations with the SF-36 scales were higher than for joint swelling scores.
Physician and patient global assessments were most highly correlated (r=0.58 and 0.66. p<0.01, respectively) with the SF-36 bodily pain item. (...)
Mots-clés Pascal : Etude transversale, Evaluation, Polyarthrite rhumatoïde, Essai clinique, Homme, Qualité vie, Validation test, Arthritis Impact Measurement Scale, Etude comparative, Health Assessment Questionnaire Stanford, Chronique, Système ostéoarticulaire pathologie, Rhumatisme inflammatoire, Immunopathologie, Maladie autoimmune, SF 36
Mots-clés Pascal anglais : Cross sectional study, Evaluation, Rheumatoid arthritis, Clinical trial, Human, Quality of life, Test validation, Arthritis Impact Measurement Scale, Comparative study, Health Assessment Questionnaire Stanford, Chronic, Diseases of the osteoarticular system, Inflammatory joint disease, Immunopathology, Autoimmune disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0536875
Code Inist : 002B15D. Création : 24/03/1998.