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  1. Maternal smoking during pregnancy, urine cotinine concentrations, and birth outcomes. A prospective cohort study.

    Article - En anglais


    Most studies of the reproductive consequences of cigarette smoking base exposure on self-reported smoking habits.

    This study examines the relationship of birth outcomes to the timing and intensity of maternal active and passive smoking estimated both from self-reports and from cotinine concentration in maternal urine during early, middle, and late gestation.


    This cohort study included 740 white and Hispanic women who obtained antenatal care at the East Boston Neighborhood Health Center between 1986 and 1992.

    At each antenatal visit, information on maternal active and passive smoking was obtained by a detailed questionnaire, and by measurement of urine cotinine concentrations.

    Infant birth outcomes were obtained from hospital records.

    Multiple linear regression was used to evaluate antenatal smoking variables on birth outcomes, with adjustment for maternal demographic characteristics, reproductive history, alcohol use, maternal weight and height, and infant gender.


    The percentage of mothers who ever smoked cigarettes during pregnancy was 55.5% for white and 10.2% for Hispanic women.

    A significant inverse exposure-response relationship between cotinine concentration in maternal urine and infant size at birth was demonstrated.

    However, the relationship was less clear between maternal self-reported smoking status and these outcomes. (...)

    Mots-clés Pascal : Tabagisme, Mère, Gestation, Cotinine, Urine, Taux, Poids naissance, Taille, Tête, Prématurité, Epidémiologie, Facteur risque, Nouveau né, Homme, Etude cohorte, Etats Unis, Amérique du Nord, Amérique, Toxicité, Biométrie

    Mots-clés Pascal anglais : Tobacco smoking, Mother, Pregnancy, Cotinine, Urine, Rate, Birth weight, Size, Head, Prematurity, Epidemiology, Risk factor, Newborn, Human, Cohort study, United States, North America, America, Toxicity, Biometrics

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 97-0534235

    Code Inist : 002B20F02. Création : 13/02/1998.