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  1. Differential features of motor neuron disease mortality in Spain.

    Article - En anglais


    The objective of this study was to describe the temporal and spatial patterns of motor neuron disease (MND) in Spain.


    We studied data where MND was stated as the principal cause of death in official statistics from Spain.

    Time trends were analysed for age-sex-specific and age-adjusted rates for the period 1951-1990.

    Age-adjusted mortality and relative risk, obtained by Poisson regression adjusting for age, were calculated for each province from deaths during the period 1975-1988.

    Maps were constructed using log transformed rates.

    Statistical significance of spatial aggregation was assessed using the Ohno et al. test.


    The 1951-1990 mortality rate, age-and sex-adjusted to the European population, for the population aged =40 years was 1.49 per 100 000 ; 1.90 and 1.21 for males and females respectively.

    In general, mortality increased with age.

    Age-adjusted rates rose until 1960, dropped by 70% during the 1960s and declined slightly over the 1951-1990 period as a whole.

    From 1970 onwards MND mortality rose evenly, particularly in the 60-69 age group.

    A North-South gradient was suggested for both sexes with statistically significant clustering in the Northern coastal regions and-for males alone-in the Midwest provinces.


    Mortality from MND in Spain displayed a magnitude and recently rising temporal trend similar to that described in several other countries. (...)

    Mots-clés Pascal : Neurone moteur maladie, Mortalité, Epidémiologie, Evolution, Variation géographique, Homme, Espagne, Europe, Système nerveux pathologie, Système nerveux central pathologie, Moelle épinière pathologie, Maladie dégénérative

    Mots-clés Pascal anglais : Motor neuron disease, Mortality, Epidemiology, Evolution, Geographical variation, Human, Spain, Europe, Nervous system diseases, Central nervous system disease, Spinal cord disease, Degenerative disease

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 97-0534223

    Code Inist : 002B17G. Création : 13/02/1998.