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  1. Risk factors for the development of non-response to first-line treatment for tuberculosis in Southern Vietnam.

    Article - En anglais

    Background

    Acquired resistance to standard chemotherapy for tuberculosis (TB) is an increasing problem worldwide.

    Vietnam has one of the highest incidences of TB and also has a large population of potential migrants to other countries.

    Since 1979 the International Organisation for Migration (IOM) has been running a supervised programme of TB treatment for intending migrants from Vietnam where few facilities for bacteriological culture and sensitivity testing exist.

    This study aimed to assess the most important factors for predicting non-response to first-line treatment as treatment starts and whether any further indicators occur during the course of treatment which may enable more accurate prediction of non-response.

    Methods

    In all, 130 subjects failing to respond to first-line therapy (cases) between 1990 and 1995 were compared with 673 subjects who responded to therapy (controls) on various demographic and clinical characteristics using logistic regression to create a prognostic index.

    Variables analysed included the patient history of past TB treatment, weight, age, sex and radiological and bacteriological findings.

    All subjects also tested negative for HIV status.

    Results

    The chief markers of successful response were x-ray signs and degree of sputum smear positivity.

    These markers provided a prognostic index with an optimal cutoff providing about 70% sensitivity and 80% specificity. (...)

    Mots-clés Pascal : Tuberculose, Mycobactériose, Bactériose, Infection, Facteur risque, Epidémiologie, Chimiothérapie, Traitement, Résistance traitement, Homme, Vietnam, Asie, Appareil respiratoire pathologie

    Mots-clés Pascal anglais : Tuberculosis, Mycobacterial infection, Bacteriosis, Infection, Risk factor, Epidemiology, Chemotherapy, Treatment, Negative therapeutic reaction, Human, Vietnam, Asia, Respiratory disease

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 97-0534202

    Code Inist : 002B02S02. Création : 13/02/1998.