Onchocerciasis is a major blinding disease in equatorial Africa and Central and South America.
Ivermectin is a safe and effective drug in the treatment of this disease and now forms the basis of disease control in most endemic areas.
We report the findings of long-term control of this infection in the Rio Santiago focus in Ecuador, between January 1990 and December 1996, using a strategy of giving ivermectin treatments biannually in hyperendemic communities and annually in meso-and hypoendemic communities.
Ivermectin was administered by local health workers from each community.
A high level of compliance to ivermectin was achieved, with 81.9% to 98.0% of those eligible receiving the drug at each treatment instance.
The impact of ivermectin therapy was monitored using a cohort of 120 randomly selected infected individuals from 8 hyperendemic communities.
The geometric mean microfilarial density of this group declined from 19.3 to 0 mf/mg over the 84-month observation period.
Ivermectin had a significant impact on anterior segment ocular disease, acute onchodermatitis and sowda.
The rate of infection of blackflies declined from 1.1% in 1989-0.08% in 1996, which is below the vectorial capacity of the Simulium vector and, as no new nodules were detected after 1994 and no children under 5 became infected over the observation period, it is likely that the transmission of this infection was interrupted in the study area.
Mots-clés Pascal : Onchocercose, Filariose, Nématodose, Helminthiase, Parasitose, Infection, Lutte sanitaire, Onchocerca volvulus, Nematoda, Nemathelminthia, Helmintha, Invertebrata, Campagne de masse, Traitement, Chimiothérapie, Ivermectine, Distribution, Equateur, Amérique du Sud, Amérique, Homme, Peau pathologie, Oeil pathologie, Antiparasitaire, Anthelminthique
Mots-clés Pascal anglais : Onchocerciasis, Filariosis, Nematode disease, Helminthiasis, Parasitosis, Infection, Sanitary control, Onchocerca volvulus, Nematoda, Nemathelminthia, Helmintha, Invertebrata, Mass campaign, Treatment, Chemotherapy, Ivermectin, Distribution, Ecuador, South America, America, Human, Skin disease, Eye disease, Parasiticid, Anthelmintic
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0534098
Code Inist : 002B02S06. Création : 13/02/1998.