The role of vasectomy in the development of prostate cancer remains controversial.
In particular, there has been concern about detection bias and confounding in the previously published epidemiological studies examining this hypothesis.
With the goal of minimizing detection bias, we have evaluated the relation between vasectomy and prostate cancer in a population without routine prostate cancer screening.
A case-control study consisting of 175 prostate cancer cases and 978 controls with cancer diagnoses other than prostate cancer was conducted at hospitals covered by the Bombay Cancer Registry in Bombay, India.
History of vasectomy, demographic, and lifestyle factors were obtained by structured interview.
Multiple logistic regression was used to estimate odds ratios (OR) and 95% confidence intervals (Cl).
Standardizing by age, 8.7% of cases and 8.3% of controls had had a vasectomy.
The OR for prostate cancer comparing men who had had a vasectomy to those who did not was 1.48 (95% Cl : 0.80-2.72) controlling for age at diagnosis, smoking status, alcohol drinking, and other demographic and lifestyle factors.
Risk of prostate cancer associated with vasectomy appeared to be higher among men who underwent vasectomy at least two decades prior to cancer diagnosis or who were at least 40 years old at vasectomy. (...)
Mots-clés Pascal : Tumeur maligne, Prostate, Vasectomie, Epidémiologie, Facteur risque, Homme, Mâle, Inde, Asie, Etude cas témoin, Appareil génital mâle pathologie, Appareil urinaire pathologie, Prostate pathologie, Chirurgie
Mots-clés Pascal anglais : Malignant tumor, Prostate, Vasectomy, Epidemiology, Risk factor, Human, Male, India, Asia, Case control study, Male genital diseases, Urinary system disease, Prostate disease, Surgery
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0533637
Code Inist : 002B20B02. Création : 13/02/1998.