Several epidemiologic studies have shown familial aggregation of prostate cancer.
To assess the nature of familial clustering of prostate cancer, a complex segregation analysis was performed on a population-based sample of 2,857 nuclear families ascertained through an affected father diagnosed with prostate cancer in Sweden during 1959-1963.
The segregation analysis, using a large, unselected population of prostate cancer families, revealed that the observed clustering of prostate cancer was best explained by a high risk allele inherited in a dominant mode, with a high population frequency (1.67%) and a moderate lifetime penetrance (63%). This study confirms the result from one earlier published segregation analysis and provides the context for interpreting the recently published linkage of hereditary prostate cancer families to chromosome 1q 24-25 (HPC1).
Mots-clés Pascal : Tumeur maligne, Prostate, Déterminisme génétique, Epidémiologie, Facteur risque, Homme, Suède, Europe, Etude familiale, Appareil génital mâle pathologie, Appareil urinaire pathologie, Prostate pathologie
Mots-clés Pascal anglais : Malignant tumor, Prostate, Genetic inheritance, Epidemiology, Risk factor, Human, Sweden, Europe, Family study, Male genital diseases, Urinary system disease, Prostate disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0533247
Code Inist : 002B14D02. Création : 13/02/1998.