Longitudinal relation between endogenous testosterone and cardiovascular disease Risk factors in middle-aged men : A 13-year follow-up of former Multiple Risk Factor Intervention Trial participants.
The present study examined lifestyle and behavioral correlates of the change in total testosterone over 13 years in 66 men aged 41-61 years who were former participants of the Multiple Risk Factor Intervention Trial (MRFIT) at the Pittsburgh, Pennsylvania, center.
The authors also determined in these men if changes in total testosterone are related to changes in cardiovascular disease risk factors.
The mean total testosterone level was 751 (standard deviation, 248) ng/dl at baseline and decreased by 41 (standard deviation, 314) ng/dl during follow-up.
The correlation between measures was r=0.44 (p<0.001).
In multivariate analysis, higher type A coronary-prone behavior score, greater pack-years of cigarette smoking, and the MRFIT special intervention group were associated with larger decreases in total testosterone.
Age, body weight, weight change, leisure time activity level, and alcohol intake were not related to the change in total testosterone.
The decrease in endogenous testosterone was associated with an increase in triglycerides and a decrease in high density lipoprotein cholesterol in multivariate analysis controlling for obesity and other lifestyle covariates.
There was little relation between change in testosterone and change in total and low density lipoprotein cholesterol or blood pressure. (...)
Mots-clés Pascal : Testostérone, Androgène, Hormone stéroïde sexuelle, Taux, Facteur risque, Appareil circulatoire pathologie, Homme, Etude longitudinale, Epidémiologie, Pennsylvanie, Etats Unis, Amérique du Nord, Amérique, Mode de vie, Comportement
Mots-clés Pascal anglais : Testosterone, Androgen, Sex steroid hormone, Rate, Risk factor, Cardiovascular disease, Human, Follow up study, Epidemiology, Pennsylvania, United States, North America, America, Life habit, Behavior
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0533008
Code Inist : 002B12A09. Création : 13/02/1998.