Pesticide prioritization for a brain cancer case-control study.
The incidence of brain cancer is rising in the United States while the causes remain largely unknown.
Epidemiologic studies indicate that individuals working in agriculture have an increased risk of brain cancer.
The National Institute for Occupational Safety and Health is conducting a case-control study of incident brain cancer cases in Iowa, Michigan, Minnesota, and Wisconsin to evaluate the risk associated with several environmental exposures, in particular agricultural pesticides.
Hundreds of different pesticides are used in agriculture and it is not feasible to evaluate the association between brain cancer and exposure to each of these chemicals ; therefore, a strategy was developed to identify which pesticides would be targeted in the study.
First, lists of pesticides were created, documenting usage in each of the four states and the United States as a whole, by using data from reports prepared by the U.S. Department of Agriculture and Departments of Agriculture and land grant colleges within the four states.
Then the following factors were considered in prioritizing pesticides for evaluation in the study : total volume of use prior to 1985, ranking of use in the four states and the United States as a whole by pesticide category, and toxicological evidence of carcinogenic, teratogenic, or mutagenic effects.
Pesticide usage prior to 1985 was determined to allow for a minimum 10-year latency for the incident brain cancer cases diagnosed in 1995 or later. (...)
Mots-clés Pascal : Pesticide, Toxicité, Homme, Tumeur maligne, Intracrânien, Etats Unis, Amérique du Nord, Amérique, Incidence, Epidémiologie, Etiologie, Agriculture, Liste, Questionnaire, Etude cas témoin, Système nerveux pathologie, Système nerveux central pathologie, Encéphale pathologie
Mots-clés Pascal anglais : Pesticides, Toxicity, Human, Malignant tumor, Intracranial, United States, North America, America, Incidence, Epidemiology, Etiology, Agriculture, List, Questionnaire, Case control study, Nervous system diseases, Central nervous system disease, Cerebral disorder
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0532842
Code Inist : 002B03G. Création : 13/02/1998.