Recent epidemiologic studies reported that the risk of venous thromboembolism (VTE) was higher with the use of the newer third generation oral contraceptives than with second generation agents.
Although the overall findings of these studies are similar, the results, as they relate to patterns and duration of oral contraceptive use particularly among first-time users, are inconsistent.
We reanalyzed data from the Transnational case-control study to assess the risk of VTE associated with first-time use of oral contraceptives as a function of its duration of use.
Over the period 1993 to 1995,471 cases of venous thromboembolism were identified in Germany and the United Kingdom.
For each case, up to four controls were obtained, for a total of 1772 controls.
Data on oral contraceptive use and confounding variables, including data on sociodemographic, lifestyle, medical history, and family history of disease, were obtained by interview.
Data analysis was based on the 105 cases and 422 controls who were first-time users of second or third generation agents, or never users of oral contraception.
Rate ratios, adjusted for confounders and approximated by odds ratios, were estimated as a continuous function of duration of oral contraceptive use by logistic regression and quadratic spline models. (...)
Mots-clés Pascal : Thromboembolie, Thrombose profonde, Toxicité, Contraceptif, Voie orale, Epidémiologie, Homme, Femelle, Oestroprogestatif, Progestatif, Oestrogène, Ethinylestradiol, Désogestrel, Gestodène, Etude comparative, Appareil circulatoire pathologie, Vaisseau sanguin pathologie, Veine pathologie, Lévonorgestrel, Norgestimate, Etude multicentrique, Progestatif troisième génération, Progestatif deuxième génération
Mots-clés Pascal anglais : Thromboembolism, Deep vein thrombosis, Toxicity, Contraceptive, Oral administration, Epidemiology, Human, Female, Estroprogestagen, Progestagen, Estrogen, Ethinylestradiol, Desogestrel, Gestodene, Comparative study, Cardiovascular disease, Vascular disease, Venous disease, Levonorgestrel, Norgestimate, Multicenter study
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0531839
Code Inist : 002B02U03. Création : 13/02/1998.