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  1. Investigation of the association of the CRTM and CRTL1 genes with radiographically evident osteoarthritis in subjects from The Rotterdam Study.

    Article - En anglais

    Objective

    To investigate whether radiographically evident osteoarthritis (ROA) in 55-65-year-old men and women is associated with specific alleles or genotypes of the cartilage matrix protein (CRTM) and cartilage link protein (CRTLI) genes.

    Methods

    Cases were selected from a population-based study on the presence of ROA of the knee or hip.

    Further radiographic analysis included scoring for spine and hand ROA.

    Controls, selected from the same population, were free of ROA in all joints.

    Results

    The CRTM locus was significantly associated with hip ROA in men (odds ratio 0.50,95% confidence interval 0.26-0.95).

    A significant association between ROA and the CRTLI gene was not observed.

    Conclusion

    These results suggest that the CRTM locus may play a role in the sex-and joint site-specific pattern of ROA development.

    Mots-clés Pascal : Arthrose, Pathogénie, Homme, Radiographie, Genou, Hanche, Epidémiologie, Exploration, Déterminisme génétique, Membre inférieur, Système ostéoarticulaire pathologie, Arthropathie, Maladie dégénérative, Radiodiagnostic, Gène CRTM, Gène CRTL1

    Mots-clés Pascal anglais : Osteoarthritis, Pathogenesis, Human, Radiography, Knee, Hip, Epidemiology, Exploration, Genetic inheritance, Lower limb, Diseases of the osteoarticular system, Arthropathy, Degenerative disease, Radiodiagnosis

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 97-0529647

    Code Inist : 002B15E. Création : 13/02/1998.