Ductal carcinoma in situ (DCIS) accounts for approximately 12% of newly diagnosed breast cancers.
Knowledge of the factors that predict who will be diagnosed with DCIS is very limited.
The goal of this study was to determine risk factors associated with DCIS and whether these risk factors are similar to those associated with invasive breast cancer.
We conducted a cross-sectional study of 39542 women aged 30 years and older who underwent a screening mammographic examination at the University of California San Francisco Mobile Mammography Screening Program from April 1985 through September 1995.
A breast cancer risk profile and clinical history were obtained for each woman.
Follow-up after abnormal mammography was performed to determine the presence of DCIS or invasive breast cancer by contacting the women's physicians and by linkage to the regional Surveillance, Epidemiology, and End Results cancer registry.
Multivariate analysis was performed by the use of polytomous logistic regression.
Two-sided statistical tests were used to determine P values.
Among women aged 30-49 years, a family history of breast cancer (i.e., at least one affected first degree relative) was associated with an increased risk of DCIS (Odds ratio [OR]=2.4 ; 95% confidence interval [CI]=1.1-4.9) and body mass index greater than or equal to 25 kg/m2 was associated with a decreased risk of DCIS (OR=0.4,95% Cl=0.2 to 0.9). (...)
Mots-clés Pascal : Carcinome canalaire, Glande mammaire, Cancer in situ, Facteur risque, Epidémiologie, Histoire familiale, Indice masse corporelle, Masse, Age, Gestation, Nulliparité, Etats Unis, Amérique du Nord, Amérique, Etude comparative, Homme, Tumeur maligne, Glande mammaire pathologie, Cancer invasif
Mots-clés Pascal anglais : Ductal carcinoma, Mammary gland, Carcinoma in situ, Risk factor, Epidemiology, Family story, Body mass index, Mass, Age, Pregnancy, Nulliparity, United States, North America, America, Comparative study, Human, Malignant tumor, Mammary gland diseases
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0529611
Code Inist : 002B20E02. Création : 13/02/1998.