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  1. Intrauterine environment and breast cancer risk in women : A population-based study.

    Article - En anglais

    Background 

    The established risk factors for female breast cancer, including nulliparity, age at first birth, age at menarche, and age at menopause, do not adequately explain the occurrence pattern of this cancer.

    Therefore, additional factors need to be considered to advance our understanding of the causes of breast cancer.

    Evidence obtained from animals and humans indicates that the perinatal period may be particularly important.

    Our earlier studies, based on a subsample of the present investigation, suggested that factors thought to be positively associated with estrogen levels during pregnancy are positively associated with breast cancer risk.

    However, the associated confidence intervals (CIs) were generally wide, indicating considerable variability in the data.

    Purpose 

    We studied a large number of incident breast cancer case patients and evaluated several perinatal variables in relation to breast cancer risk.

    These variables included some not previously studied, such as gestational age and neonatal jaundice.

    We also investigated twin membership as a predictor variable and death from breast cancer, in addition to occurrence of breast cancer, as an alternative outcome variable.

    Methods 

    Birth records for all deliveries at five different hospitals in Sweden during the period from 1874 through 1961 were used to define a large cohort of women. (...)

    Mots-clés Pascal : Tumeur maligne, Glande mammaire, Facteur risque, Ictère, Néonatal, Age gestation, Epidémiologie, Jumeau, Etude cas témoin, Suède, Europe, Homme, Glande mammaire pathologie

    Mots-clés Pascal anglais : Malignant tumor, Mammary gland, Risk factor, Jaundice, Neonatal, Gestational age, Epidemiology, Twin, Case control study, Sweden, Europe, Human, Mammary gland diseases

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 97-0529610

    Code Inist : 002B20E02. Création : 13/02/1998.