Analysis of aluminium in serum and urine for the biomonitoring of occupational exposure.
International Symposium on Biological Monitoring in Occupational and Environmental Health. Espoo (FIN), 1996/09/11.
Copyright (c) 1997 Elsevier Science B.V. All rights reserved.
A reliable and sensitive graphite furnace atomic absorption spectrometry (GFAAS) method with Zeeman background correction was developed for the analysis of aluminium in serum and urine in the biological monitoring of aluminium exposure.
The method is based on platform atomisation in pyrolytically coated graphite tubes after fourfold dilution with nitric acid.
For serum analysis, a matrix matched standard curve is prepared and for urine the method of standard additions is used.
The within-run imprecision (C.V.) for serum and urine was 3% and 5%, and the between-day imprecision, 6% and 7.2%, at a concentration level of 4.0 mumol/l. The between-day imprecision for urinary aluminium was 15.7% at a concentration level of 0.24 mumol/l. The detection limits were 0.02 mumol/l for serum and 0.07 mumol/l for urine.
During 1 year of participation in TEQAS external quality assessment scheme of the Robens Institute for Health and Safety (Guildford, UK) for serum aluminium the maximum cumulative performance score was achieved.
For urinary aluminium a certificate in the external quality control scheme of the German Society of Occupational Medicine was obtained.
The mean concentration of aluminium in a non-exposed population, who did not use antacid drugs, was 0.06 mumol/l (S.D. 0.03, range 0.02-0.13, n=21) in serum, and 0.33 mumol/l (S.D. 0.18, range 0.07-0.82, n=44) in urine. (...)
Mots-clés Pascal : Aluminium, Métal léger, Exposition professionnelle, Médecine travail, Surveillance biologique, Analyse quantitative, Liquide biologique, Sérum, Sang, Urine, Homme, Effet Zeeman
Mots-clés Pascal anglais : Aluminium, Light metal, Occupational exposure, Occupational medicine, Biological monitoring, Quantitative analysis, Biological fluid, Serum, Blood, Urine, Human, Zeeman effect
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Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0528851
Code Inist : 002B03L05. Création : 13/02/1998.