International Symposium on Biological Monitoring in Occupational and Environmental Health. Espoo (FIN), 1996/09/11.
Copyright (c) 1997 Elsevier Science B.V. All rights reserved.
The purpose of this study was to compare different biological methods in current use to assess benzene exposure.
The methods involved in the study were : benzene in blood, urine and exhaled air, and the urinary metabolites t, t-muconic acid (MA) and S-phenylmercapturic acid (S-PMA).
Blood, urine and exhaled air samples were collected from workers in a benzene plant (pure benzene exposure) and cokery (mixed exposure, e.g. polycyclic aromatic hydrocarbons - PAHs) in an Estonian shale oil petrochemical plant.
The benzene in these samples was analysed with a head-space gas chromatograph, and the metabolites MA and iS-PMA with a liquid chromatograph using methods developed from published procedures.
Some of the values measured in the Estonian shale oil area were high in comparison with those published during the last few years, whereas the values measured in the control group did not show any exposure to benzene except in the smokers group.
The highest median exposure was in the benzene factory, 0.9 cm 3/m3 TWA (2.9 mg/m3) and the highest individual value was 15 cm u3/m3 TWA (49 mg/m3).
All biological measurements in this study gave the same assessment about exposure to benzene and correlated highly significantly with each other and with the air measurements (r=0.8 or more).
In the benzene factory the correlation was good even when calculated from samples with air concentration<1 cm3/m3 (3. (...)
Mots-clés Pascal : Benzène, Cokerie, Industrie chimique, Exposition professionnelle, Médecine travail, Homme, Surveillance biologique, Liquide biologique, Matériel biologique, Urine, Sang, Air expiré, Métabolite, Muconique acide, Mercapturique acide
Mots-clés Pascal anglais : Benzene, Coking plant, Chemical industry, Occupational exposure, Occupational medicine, Human, Biological monitoring, Biological fluid, Biological material, Urine, Blood, Expired air, Metabolite
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0528846
Code Inist : 002B03L04. Création : 13/02/1998.