Neuropsychiatric syndromes and occupational exposure to zinc phosphide in Egypt.
International Symposium on Neurobehavioral Methods and Effects in Occupational and Environmental Health. Cairo (EGY), 1994/12/03.
Eighty-six workers exposed to zinc phosphide (Zn3P2) pesticide were studied for evidence of neuropsychiatric manifestations.
They were evaluated clinically, by electroencephalography (EEG), and, in some cases, by electromyography (EMG).
All were males (mean age, 35.8 years ; mean duration of exposure to zinc phosphide, 11.3 years).
Most presented with one (or more) neuropsychiatric symptom (s), including fear of poisoning, anxiety, impotence, and easy fatigue.
About half showed evidence of neuropsychiatric signs, including hyperreflexia, polyneu-ropathy, lumber radiculopathy, and cervical my-elopathy, as well as anxious mood, impaired attention, and psychomotor stimulation.
EEG recordings showed abnormal findings in 17.4% of the subjects.
The mean age in that group was 39.1 years ; mean duration of exposure to Zn3P2 was 15.1 years.
EMG studies showed evidence of partial denervation of the anterior tibial group of muscles and flexor digiti minimi in 2 of the 30 workers (6.7%) who underwent EMG examination.
Serum levels of zinc (Zn) and cadmium (Ca) were significantly higher in exposed workers than in controls (P<0.005).
Serum copper (Cu), iron (Fe), phosphorus (P), and magnesium (Mg) were significantly lower in exposed workers than in controls.
Electrophoretic pattern of globulin showed that gammaglobulin fraction was significantly increased (P<0.005) ; alpha2 and bêta-globulin were decreased (P<0.005) in exposed workers. (...)
Mots-clés Pascal : Pesticide, Zinc Phosphure, Rodenticide, Exposition professionnelle, Médecine travail, Toxicité, Homme, Trouble psychiatrique, Electroencéphalographie, Electromyographie, Egypte, Afrique, Système nerveux pathologie
Mots-clés Pascal anglais : Pesticides, Zinc Phosphides, Rodenticide, Occupational exposure, Occupational medicine, Toxicity, Human, Mental disorder, Electroencephalography, Electromyography, Egypt, Africa, Nervous system diseases
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Cote : 97-0527944
Code Inist : 002B03G. Création : 13/02/1998.