International Symposium on Neurobehavioral Methods and Effects in Occupational and Environmental Health. Cairo (EGY), 1994/12/03.
A cross-sectional study was conducted in 35 male subjects randomly selected from workers of a ferroalloy production plant and exposed to manganese (Mn) oxides ; the objective was to detect early signs of neurologic impairment.
The subjects'mean age was 39.4 years (SD, 8.4) ; the average exposure duration was 14.5 years (range, 5-29 years).
A control group of industrial workers not exposed to neurotoxic chemicals and comparable in age and confounding factors was recruited.
The intensity of Mn exposure was moderate, as reflected by airborne Mn concentrations in total dust averaging 93 mug/m3.
Mn levels in blood (MnB) and urine (MnU) were significantly higher in the Mn-exposed workers than in control workers.
A relationship (not found with MnU) was found between MnB and a cumulative exposure index calculated on the basis of air concentration and exposure history for each subject (r=0.52 ; r2=0.27 ; P=0.002).
Psychomotor function scores were lower among Mn-exposed subjects.
The Aiming score was negatively correlated with MnB in the exposed group.
The olfactory threshold did not differ between the two groups, although it was negatively associated with MnU in the exposed group.
The white blood cell count results were significantly higher in Mn-exposed subjects than in controls.
These findings show that an increase in Mn body burden is associated with an impairment of motor functions, whereas the increased excretion of Mn is related to an increased olfactory perception. (...)
Mots-clés Pascal : Manganèse, Toxicité, Homme, Exposition professionnelle, Médecine travail, Ferroalliage, Industrie métallurgique, Neurone moteur, Trouble odorat, Olfaction, Hématologie, Hémopathie, Système nerveux pathologie
Mots-clés Pascal anglais : Manganese, Toxicity, Human, Occupational exposure, Occupational medicine, Ferro alloy, Metallurgical industry, Motor neuron, Olfactory disorder, Olfaction, Hematology, Hemopathy, Nervous system diseases
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Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0527422
Code Inist : 002B03L05. Création : 13/02/1998.