Risk of Kaposi's sarcoma-associated herpes virus transmission from donor allografts among italian posttransplant Kaposi's sarcoma patients.
Kaposi's sarcoma-associated herpesvirus (KSHV) is a newly discovered herpes virus found in all forms of Kaposi's sarcoma (KS) including KS among immunosuppressed transplant patients.
It is unknown whether this virus is transmitted by organ transplantation or is reactivated during immunosuppression among those patients infected before transplantation.
To investigate the risk of KSHV transmission during organ transplantation, we conducted a case-control study of transplant recipients with and without KS matched to their respective donors.
Sera were collected at time of transplantation and tested in a randomized and blinded fashion using four KSHV serologic assays testing for antibodies to both latent and lytic phase antigens.
Ten (91%) of 11 organ recipients who developed KS were seropositive prior to transplantation by one or more of the assays compared with two (12%) of 17 control organ recipients (OR=75,95% CI=4.7,3500).
KS cases were more likely to have been born in southern Italy where KS is endemic than the recipient controls or either donor group.
Only four (36%) of 11 donors to case patients and three (18%) of 17 donors to control patients were seropositive (P=38, two-tailed Fisher's exact test).
KSHV transmission could not be ruled out for the single KS patient seronegative at transplantation and clear evidence for organ-related transmission was found for another KS patient outside of the case-control study. (...)
Mots-clés Pascal : Kaposi maladie, Herpesvirus hominis, Alphaherpesvirinae, Herpesviridae, Virus, Virose, Infection, Facteur risque, Epidémiologie, Italie, Europe, Transplantation, Homotransplantation, Organe, Transmission homme homme, Etude cas témoin, Homme, Peau pathologie, Tumeur maligne, Chirurgie, Herpesvirus hominis 8
Mots-clés Pascal anglais : Kaposi sarcoma, Herpesvirus hominis, Alphaherpesvirinae, Herpesviridae, Virus, Viral disease, Infection, Risk factor, Epidemiology, Italy, Europe, Transplantation, Homotransplantation, Organ, Transmission from man to man, Case control study, Human, Skin disease, Malignant tumor, Surgery
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0527412
Code Inist : 002B08A. Création : 13/02/1998.