Effects of prenatal methylmercury exposure from a high fish diet on developmental milestones in the Seychelles child development study.
Mercury is widespread in the environment and exists in several physical and chemical forms.
Prenatal exposure to methylmercury disrupts brain development.
The most common mode of prenatal methylmercury exposure is maternal fish consumption.
Studies of human prenatal exposure in Iraq following maternal ingestion of methylmercury treated grain suggested that maternal hair mercury concentrations above 10 ppm may be related to delayed developmental milestones and neurological abnormalities.
This level of exposure can be achieved by frequent consumption of fish.
The Seychelles Child Development Study analyzed developmental milestones similar to those determined in Iraq in a large controlled, prospective study of children exposed prenatally to methylmercury when their mothers ate fish.
As part of this ongoing study, cohort children were evaluated at 6.5,19,29, and 66 months of age.
At 19 months care-givers were asked at what age the child walked (n=720 out of 738) and talked (n=680).
Prenatal mercury exposure was determined by atomic absorption analysis ofmaternal hair segments corresponding to hair growth during the pregnancy.
The median mercury level in maternal hair was 5.8 ppm with a range of 0.5 - 26.7 ppm.
The mean age (in months) at walking was 10.7 (SD=1.9) for females and 10.6 (SD=2.0) for males.
The mean age at talking (in months) was 10.5 (SD=2.6) for females, and 11.0 (SD=2.9) for males. (...)
Mots-clés Pascal : Mercure Composé organique, Métal lourd, Contamination, Gestation, Passage mère embryon, Stade développement, Epidémiologie, Descendance, Développement postnatal, Tératogenèse, Homme, Exposition, Prénatal, Seychelles, Iles Océan Indien, Produit pêche, Aliment, Poisson comestible, Mercure(méthyl)
Mots-clés Pascal anglais : Mercury Organic compounds, Heavy metal, Contamination, Pregnancy, Mother embryonal transfer, Developmental stage, Epidemiology, Progeny, Postnatal development, Teratogénesis, Human, Exposure, Prenatal, Seychelles, Indian Ocean Islands, Seafood, Food, Edible fish
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0527337
Code Inist : 002A30E. Création : 13/02/1998.