The relationship between diabetes mellitus and primary liver cancer was investigated in a case-control study conducted in Italy between 1984 and 1996 on 428 cases with incident, histologically confirmed hepatocellular carcinoma, 59 with gallbladder and bile duct cancer, and 1,502 control subjects in the hospital for acute non-neoplastic diseases.
Sixty-four cases of hepatocellular carcinoma vs. 87 controls reported a history of diabetes, corresponding to an odds ratio (OR) of 2.3 after allowance for age, sex and area of residence, and of 2.1 [95% confidence interval (Cl)=1.4-3.2] after further allowance for alcohol and tobacco consumption, history of hepatitis and liver cirrhosis, body mass index and history of liver cancer in first-degree relatives.
The ORs were similar both for subjects diagnosed with diabetes below age 45, who most likely had insulin-dependent diabetes, and for those diagnosed later, who were likelier to have non-insulin-dependent diabetes.
The OR was 2.3 for subjects whose diabetes was diagnosed<5 years before diagnosis of liver cancer, 1.9 for those diagnosed 5-9 years in advance and 2.2 for those diagnosed since 10 years or more.
Five cases of gallbladder and bile duct cancer reported a history of diabetes : the corresponding OR was 1.2 (95% Cl 0.5-2.9).
The OR of hepatocellular carcinoma was 2.4 for males and 2.0 for females, 3.0 for subjects diagnosed with liver cancer under age 60 and 1.8 for those diagnosed at age 60 or over. (...)
Mots-clés Pascal : Carcinome hépatocellulaire, Facteur risque, Epidémiologie, Diabète, Italie, Europe, Etude cas témoin, Homme, Appareil digestif pathologie, Foie pathologie, Tumeur maligne, Endocrinopathie
Mots-clés Pascal anglais : Hepatocellular carcinoma, Risk factor, Epidemiology, Diabetes mellitus, Italy, Europe, Case control study, Human, Digestive diseases, Hepatic disease, Malignant tumor, Endocrinopathy
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0527054
Code Inist : 002B13C01. Création : 13/02/1998.