We studied overall and cause-specific mortality rates in a large cohort of patients with epilepsy compared with mortality rates of the general population in the same geographic area.
The cohort consisted of all patients (N=9,061) aged>15 years admitted with a diagnosis of epilepsy for inpatient care in Stockholm during the years 1980-1989.
All patients were followed in the National Cause-of-Death Register, from which the causes of death were obtained, until December 31,1992.
Thus, 53,520 person-years were observed.
Mortality rates were compared with those of the general population of Stockholm.
We observed 4,001 deaths in the cohort, compared with an expected number of 1,109 deaths in the general population.
This yielded a standardized mortality ratio (SMR) of 3.6 [95% confidence interval (Cl) 3.5-3.7]. Although highest in the younger patients, the SMR was significantly increased in all age groups.
The excess mortality rate in the cohort was due to a wide range of causes of death, including malignant neoplasms [SMR 2.6 (2.4-2.8) 1, diseases of the circulatory system, [SMR 3.1 (3.0-3.3) ], diseases of the respiratory system [SMR 4.0 (3.6-4.5) ], diseases of the digestive system [SMR 5.1 (4.4-5.8) ], and injuries and poisoning [SMR 5.6 (5.0-6.3) ]. (...)
Mots-clés Pascal : Epilepsie, Mortalité, Age, Suède, Europe, Etude cohorte, Etude comparative, Epidémiologie, Etiologie, Homme, Système nerveux pathologie, Système nerveux central pathologie, Encéphale pathologie
Mots-clés Pascal anglais : Epilepsy, Mortality, Age, Sweden, Europe, Cohort study, Comparative study, Epidemiology, Etiology, Human, Nervous system diseases, Central nervous system disease, Cerebral disorder
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0524005
Code Inist : 002B17A03. Création : 13/02/1998.