Prognostic factors for toluene diisocyanate-induced occupational asthma after removal from exposure.
Background The outcome of isocyanate-induced occupational asthma remains to be further defined.
There have been few studies on the role of specific antibodies in prognosis of toluene diisocyanate (TDI) induced occupational asthma.
Moreover, to the best of our knowledge, there have been no studies on the improvement pattern of airway hyperresponsiveness (AH).
We analysed the prognostic factors that affected the outcome of 35 toluene diisocyanate-induced occupational asthma.
Objectives To define clinical and laboratory parameters predicting favourable prognosis for TDI-induced occupational asthma.
Methods and results After confirmation of bronchial sensitivity by TDI bronchoprovocation test (BPT), 35 patients were recommended to avoid exposure to TDI ; they were also given anti-asthmatic medications including inhaled steroids and monitored for 2 years.
Seventeen (49%) recovered completely with disappearance of airway hyperresponsiveness (AH) to methacholine during the follow-up period (mean duration : 12 months, range of 3-30 months).
Eleven (31%) showed a significant improvement in AH for first year, which improvement stabilized in the next year with mild symptoms.
Seven (20%) patients did not show any evidence of improvement in AH and had persistent symptoms.
Favourable prognosis was associated with a short duration of asthmatic symptoms before diagnosis (P<0.05), immediate cessation of exposure after diagnosis (P<0.05), milder degree of AH at diagnosis (P<0. (...)
Mots-clés Pascal : Asthme, Diisocyanate organique, Composé chimique, Allergie, Toxicité, Exposition professionnelle, Corée, Asie, Pronostic, Homme, Appareil respiratoire pathologie, Bronchopneumopathie obstructive, Maladie professionnelle, Médecine travail, Immunopathologie, Toluène(diisocyanato)
Mots-clés Pascal anglais : Asthma, Organic diisocyanate, Chemical compound, Allergy, Toxicity, Occupational exposure, Korea, Asia, Prognosis, Human, Respiratory disease, Obstructive pulmonary disease, Occupational disease, Occupational medicine, Immunopathology
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0523982
Code Inist : 002B06C02. Création : 13/02/1998.