Association between genetic polymorphism of the pepsinogen C gene and gastric body ulcer : the genetic predisposition is not associated with Helicobacter pylori infection.
Background and aims-The genetic trait plays a part in the pathogenesis of peptic ulcer disease.
To identify a DNA marker for peptic ulcer disease, the association between the restriction fragment length polymorphism (RFLP) of the pepsinogen C (PGC) gene and peptic ulcer disease was investigated.
Patients and methods-One hundred and seventy seven unrelated controls, 75 patients with gastric ulcer, and 70 with duodenal ulcer were studied.
PGC-RFLP was analysed by polymerase chain reaction (PCR), and the association between PGC-RFLP and peptic ulcer disease was examined.
The relation between the genetic association of PGC polymorphism with peptic ulcer and Helicobacter pylovi infection was also examined.
Four alleles, 480 (allele 1), 450 (allele 2), 400 (allele 3), and 310 bp (allele 4), were detected by PCR.
The frequency of allele 4 was significantly higher in patients with gastric body ulcer than in controls (X2=9.92, p<0.005).
Genotypes containing allele 4 were significantly more frequent in patients with gastric body ulcer than in controls and patients with gastric angular or antral ulcer.
The relative risk of gastric body ulcer associated with the presence of allele 4, compared with its absence, was 4.63 and was statistically significant (X2=14.84, p<0.005). (...)
Mots-clés Pascal : Ulcère, Estomac, Relation incertitude, Polymorphisme longueur fragment restriction, Gène, Pepsinogène, Gastrite, Campylobactériose, Bactériose, Infection, Helicobacter pylori, Spirillaceae, Spirillales, Bactérie, Déterminisme génétique, Epidémiologie, Homme, Appareil digestif pathologie, Estomac pathologie, Génétique
Mots-clés Pascal anglais : Ulcer, Stomach, Uncertainty relation, Restriction fragment length polymorphism, Gene, Pepsinogen, Gastritis, Campylobacter infection, Bacteriosis, Infection, Helicobacter pylori, Spirillaceae, Spirillales, Bacteria, Genetic inheritance, Epidemiology, Human, Digestive diseases, Gastric disease, Genetics
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0523791
Code Inist : 002B13B03. Création : 13/02/1998.