In the present study the relationship between the level of exposure to o-cresol and of 2,4-2,5-3,4-and 3,5-xylenols and the urinary excretion of their metabolites was examined.
The mixed exposure to phenolic derivatives of exposed workers during their work shift was monitored by personal air sampling of the breathing-zone air and by measurements of phenol, o-cresol, and xylenol isomer concentrations in shift-end urine.
The study subjects were 76 men working at a coke plant who were 22-58 years old and 34 nonexposed subjects.
Concentrations of phenolic compounds were determined in the breathing-zone air during the work shift, whereas concentrations of phenol, cresol, and xylenol isomers were measured in urine collected after the work shift.
Concentrations of phenols in air and urine were determined by gas chromatography with flame-ionization detection.
Urine samples were extracted after acid hydrolysis of glucuronides and sulfates by solid-phase extraction.
The gas chromatography-mass spectrometry method was applied to identify metabolites in urine samples.
The time-weighted average concentrations of phenol, cresol, and xylenol isomers detected in breathing-zone air showed that the exposure level of the workers was relatively low.
The geometric mean values were as follows : 0.26 mg/m3 for phenol, 0.09 mg/m3 for o-cresol, 0.13 mg/m3 for p-and m-cresol, and 0.02-0.04 mg/m3 for xylenols at the tar-distillation process. (...)
Mots-clés Pascal : Coke, Phénols, Exposition professionnelle, Médecine travail, Homme, Surveillance biologique, Marqueur biologique, Urine, Liquide biologique, Association toxique, o-Crésol, Xylénol
Mots-clés Pascal anglais : Coke, Phenols, Occupational exposure, Occupational medicine, Human, Biological monitoring, Biological marker, Urine, Biological fluid, Toxic association
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0523631
Code Inist : 002B03L06. Création : 13/02/1998.