To study the effect of exposure on bronchial responsiveness in pig farmers.
A group of 196 pig farmers were tested for lung function and bronchial responsiveness to histamine in the summer of 1992.
To achieve sufficient contrast in respiratory morbidity and exposure. 96 of the farmers were selected because they had chronic respiratory symptoms and the remaining 100 because they were free from any respiratory symptoms.
Personal exposure to dust, endotoxins and ammonia was measured during 1 working day in the summer of 1991 and I day in the winter of 1992.
Data on farm characteristics were gathered in the same period.
After adjusting for age and smoking behaviour, mild bronchial responsiveness, defined as PC10 ¾ 16 mg/ml, was associated with the use of quaternary ammonium compounds as disinfectant [prevalence odds ratio (POR) 6.7,95% confidence interval (CI) 1.4-32.8], use of wood-shavings as bedding (POR 13.3, CI 1.3-136.7), use of automated dry feeding (POR 2.8, CI 1.0-7.8), use of pellets as feeding material (POR 4.8, CI 1.1-21.1) and location of air exhaust via pit or roof in the confinement units (POR 2.7, CI 1.2-6.3).
The association with the use of disinfectants other than quaternary ammonium compounds was not significant (POR 2.4, CI 0.7-8.4).
No associations between bronchial responsiveness and measured exposure to dust, endotoxins or ammonia were discernible. (...)
Mots-clés Pascal : Agriculteur, Porcherie, Animal élevage, Exposition professionnelle, Médecine travail, Poussière, Endotoxine, Ammoniac, Toxicité, Homme, Confinement, Fonction respiratoire, Bronche, Hypersensibilité, Appareil respiratoire pathologie, Prévalence
Mots-clés Pascal anglais : Farmer, Pig barn, Farming animal, Occupational exposure, Occupational medicine, Dust, Endotoxin, Ammonia, Toxicity, Human, Confinement, Lung function, Bronchus, Hypersensitivity, Respiratory disease, Prevalence
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0523630
Code Inist : 002B03L03. Création : 13/02/1998.