logo BDSP

Base documentaire

  1. Serotonin reuptake inhibitors and the adequacy of antidepressant treatment.

    Article - En anglais


    To determine whether the use of serotonin reuptake inhibitors (SSRIs) improves antidepressant medication prescribing patterns for both psychiatric and non-psychiatric physicians.

    Data Sources/Setting 

    Drug utilization review of 4,103 prescriptions for antidepressant medications with patients diagnosed with depressive disorders over an eighteen-month period from the formulary records of a large insurance company.


    Using standards developed for clinical guidelines, variation in trial and treatment adequacy between drug types and physician specialty was studied.

    Principal Findings 

    Thirty-five percent of initial antidepressant trials were not prescribed for an adequate duration or at an adequate dosage level.

    SSRIs were more likely to be prescribed adequately than any other antidepressant reviewed.

    Psychiatrists were more likely to prescribe antidepressants at an adequate dosage level, whereas non-psychiatric physicians were more likely to attain adequate duration of treatment.


    A greater reliance on SSRIs may increase the likelihood of maintaining adequacy in antidepressant treatments.

    Although higher in cost than other treatment choices, their lower side effect profile is likely to maximize patient satisfaction and physician and patient adherence to guidelines.

    In order to ensure effective and efficient antidepressant usage, such patterns must be identified and appropriate performance improvement strategies. (...)

    Mots-clés Pascal : Prescription médicale, Antidépresseur, Psychotrope, Inhibiteur recapture, Sérotonine, Psychiatre, Etude comparative, Médecin, Chimiothérapie, Traitement, Homme

    Mots-clés Pascal anglais : Medical prescription, Antidepressant agent, Psychotropic, Reuptake inhibitor, Serotonin, Psychiatrist, Comparative study, Physician, Chemotherapy, Treatment, Human

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 97-0522531

    Code Inist : 002B02B02. Création : 13/02/1998.