Effects of occupational lead and cadmium exposure on some immunoregulatory cytokine levels in man.
The levels of serum interleukin-1bêta (IL-1bêta), interleukin-2 (IL-2), tumor necrosis factor alpha (TNF-alpha) and gamma-interferon (gamma-IFN) were assessed in the workers who were occupationally exposed to lead and cadmium.
The values were compared with the age-matched control group.
Blood lead and cadmium levels were significantly raised.
Our findings suggest that chronic lead and cadmium exposure in humans resulted in significant suppression of the serum IL-1bêta level, but did not alter IL-2 and TNF-alpha levels.
The gamma-IFN level was also reduced in lead workers.
In contrast, a significant enhancement was observed in the cadmium-exposed group.
We conclude from these results that lead and cadmium exposure at chronically high level may affect some cytokine levels in humans.
Mots-clés Pascal : Plomb, Métal lourd, Cadmium, Toxicité, Homme, Exposition professionnelle, Médecine travail, Interleukine 1bêta, Interleukine 2, Facteur nécrose tumorale alpha, Interféron gamma, Cytokine, Réponse immune
Mots-clés Pascal anglais : Lead, Heavy metal, Cadmium, Toxicity, Human, Occupational exposure, Occupational medicine, Interleukin 1bêta, Interleukin 2, Tumor necrosis factor alpha, Gamma interferon, Cytokine, Immune response
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0521277
Code Inist : 002B03L05. Création : 13/02/1998.