This study investigated a previously reported 50% or more increased risk for neural tube defect-affected pregnancies among Latina women compared with White women.
Data were derived from a population-based case-control study of fetuses and live-born infants with neural tube defects in a 1989-through-1991 California birth cohort.
Interviews were conducted with mothers of 538 (88% of eligible) infants/fetuses with neural tube defects and mothers of 539 (88%) nonmalformed control infants.
The risk for a neural tube defect-affected pregnancy was approximately twice as high among women of Mexican descent than among White women (odds ratio=1.9,95% confidence interval [CI]=1.5,2.8).
The odds ratio for Mexico-born Mexican women compared with White women was 2.4 (95% CI=1.7,3.2), whereas the risk for US-born women of Mexican and other racial/ethnic descent was not substantially higher than that for Whites.
The higher risk among Mexico-born Mexican women was not attributable to differences in numerous studied parental characteristics and exposures.
Given that nearly 20% of all California births are to Mexico-born Mexican women, the increased risks observed are relevant to the population burden of neural tube defects.
Mots-clés Pascal : Tube neural, Anomalie, Foetus pathologie, Gestation pathologie, Ethnie, Caucasoïde, Latinoaméricain, Epidémiologie, Facteur risque, Prévalence, Nouveau né, Homme, Nouveau né pathologie, Etude comparative, Californie, Etats Unis, Amérique du Nord, Amérique, Maladie congénitale, Malformation
Mots-clés Pascal anglais : Neural tube, Anomaly, Fetal diseases, Pregnancy disorders, Ethnic group, Caucasoid, Latinamerican, Epidemiology, Risk factor, Prevalence, Newborn, Human, Newborn diseases, Comparative study, California, United States, North America, America, Congenital disease, Malformation
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0515385
Code Inist : 002B20F02. Création : 13/02/1998.