A prospective study of pregravid determinants of gestational diabetes mellitus.
Context-Gestational diabetes mellitus (GDM) affects 3% to 5% of pregnancies.
Knowledge of risk factors for GDM is needed to identify possible preventive strategies.
To assess whether recognized determinants of non-insulin-dependent diabetes mellitus also may be markers for increased risk of GDM.
- Prospective cohort study.
Selling. - The Nurses'Health Study II, which involves female US nurses aged 25 to 42 years at entry.
- - The analyses included 14 613 women without previous GDM or other known diabetes who reported a singleton pregnancy between 1990 and 1994.
Of these women, 722 (4.9%) reported a new diagnosis of GDM.
Main Outcome Measure
Self-report of GDM, validated by medical record review in a subset.
In multivadate analyses including age, pregravid body mass index (BMI), and other GDM risk factors, the risk for GDM increased significantly with increasing maternal age (P for trend,<. 01) and family history of diabetes mellitus (relative risk, 1.68 ; 95% confidence interval [C Ii, 1.39-2.04).
Relative risks for GDM were 2.13 (95% Cl, 1.65-2.74) for pregravid BMI of 25 to 29.9 kg/m2and 2.90 (95% Cl, 2.15-3.91) for BMI of 30 kg/m2 or more (vs BMI of<20 kg/m2).
Risk for GDM increased with greater weight gain in early adulthood, and it also increased among nonwhite women.
Pregravid current smokers had a relative risk for GDM of 1.43 (95% Cl, 1.14-1. (...)
Mots-clés Pascal : Diabète non insulinodépendant, Association, Gestation, Facteur risque, Etude cohorte, Prospective, Prévention, Femelle, Homme, Endocrinopathie, Appareil génital femelle pathologie
Mots-clés Pascal anglais : Non insulin dependent diabetes, Association, Pregnancy, Risk factor, Cohort study, Prospective, Prevention, Female, Human, Endocrinopathy, Female genital diseases
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0515324
Code Inist : 002B21E01B. Création : 13/02/1998.