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  1. Transmission of a highly drug-resistant strain (strain W1) of Mycobacterium tuberculosis : Community outbreak and nosocomial transmission via a contaminated bronchoscope.

    Article - En anglais


    Nosocomial transmission of multidrug-resistant tuberculosis (MDR TB) has been reported primarily in New York State and has generally been presumed to occur via respiratory aerosols.


    - To assess nosocomial transmission of MDR TB.

    In 1995,8 patients with MDR TB were identified ih South Carolina ; all were resistant to 7 drugs and had matching DNAfingerprints (strain W1).

    Community links were identified for patients (Patients 1-5).

    However, no links were identified for the other 3 patients (Patients 6-8) except being hospitalized at the same hospital as 1 community patient.


    - Outbreak investigation.


    - Community and hospital.


    - Eight patients whose MDR TB isolates had DNA fingerprint patterns matching strain W1.

    Main Outcome Measures

    Clinical characteristics of patients with strain W1 Mycobacterium tuberculosis isolates.


    - Patient 5 (community patient) and Patient 8, diagnosed April 1995 and November 1995, respectively, had clinical courses consistent with MDR TB, with smear-positive and culture-positive specimens and cavitary lesions on chest radiograph ; both died of MDR TB less than 1 month after diagnosis.

    Patients 6 and 7 (diagnosed May 1995) each had 1 positive culture for MDR TB ; specimens were collected during bronchoscopy.

    Patient 6 had a skin test conversion after bronchoscopy. (...)

    Mots-clés Pascal : Infection nosocomiale, Mycobacterium tuberculosis, Mycobacteriaceae, Mycobacteriales, Actinomycetes, Bactérie, Facteur risque, Bronchoscope, Contamination, Résistance traitement, Enquête sur terrain, Communauté, Hôpital, Evaluation, Homme, Mycobactériose, Bactériose, Infection, Traitement instrumental

    Mots-clés Pascal anglais : Nosocomial infection, Mycobacterium tuberculosis, Mycobacteriaceae, Mycobacteriales, Actinomycetes, Bacteria, Risk factor, Bronchoscop, Contamination, Negative therapeutic reaction, Field inquiry, Community, Hospital, Evaluation, Human, Mycobacterial infection, Bacteriosis, Infection, Instrumentation therapy

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 97-0515084

    Code Inist : 002B05B02O. Création : 13/02/1998.