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  1. Fulltext. Could salicylates in food have contributed to the decline in cardiovascular disease mortality ? A new hypothesis.

    Article - En anglais

    Fulltext.

    Objectives

    The prophylactic effect of aspirin (at 80 mg/day) for the prevention of cardiovascular disease mortality has long been recognized.

    This study examined whether other salicylates are present in comparable quantities in the US food supply.

    Methods

    To estimate the order of magnitude for salicylates in the food supply, annual production data for selected synthetic salicylates were analyzed Results.

    Production figures for 1960 indicate exposure to salicylates of 259 mg/day per person, or 95 mg/day per person excluding aspirin.

    Trend data indicate a rise in the production of salicylates over time, reaching 341 mg/day per person, or 126 mg/day per person excluding aspirin, in 1970.

    Conclusions

    The US ingestion of salicylates with aspirinlike properties may have increased to the point that many susceptible individuals have received a beneficial effect that has contributed to the decline in cardiovascular disease mortality.

    Mots-clés Pascal : Mortalité, Taux, Appareil circulatoire pathologie, Salicylés, Alimentation, Aliment, Epidémiologie, Evolution, Homme, Etats Unis, Amérique du Nord, Amérique

    Mots-clés Pascal anglais : Mortality, Rate, Cardiovascular disease, Salicylates, Feeding, Food, Epidemiology, Evolution, Human, United States, North America, America

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 97-0515032

    Code Inist : 002B30A01A2. Création : 13/02/1998.