National Institutes of Health Consensus Development Conference. Bethesda (USA), 1997/03/24.
Among 248 asymptomatic blood donors positive for antibody to hepatitis C virus (anti-HCV) enrolled in a long-term prospective study, 86% had chronic HCV infection and 14% appeared to have recovered as assessed by serial determinations of serum alanine aminotransferase (ALT) levels and HCV RNA by polymerase chain reaction.
Established parenteral risk factors for HCV transmission were identified in 75% of donors.
In addition, there was a strong independent association between HCV positivity and cocaine snorting, suggesting that shared snorting devices may be a covert route of parenteral transmission.
Ear piercing in males was also significantly associated with transmission.
There was no evidence for sexual spread.
Although the majority of HCV carriers had both biochemical and histological evidence of chronic viral hepatitis, the extent of liver injury was generally mild.
Among a larger population of 280 HCV RNA-positive donors, 17% had repeatedly normal ALT levels, 45% had levels that did not exceed twice, and only 22% had levels that exceeded five times the upper limit of the normal range.
Among 81 patients who underwent liver biopsy, only 13% had evidence of severe hepatitis (8%) or cirrhosis (5%), despite a duration of infection that generally exceeded 15 years.
No severe histological lesions were observed in blood donors with chronic HCV infection who had repeatedly normal ALT levels. (...)
Mots-clés Pascal : Hépatite virale C, Virose, Infection, Virus hépatite C, Flaviviridae, Virus, Asymptomatique, Incidence, Facteur risque, Toxicomanie, Diagnostic, Dosage, RNA, Transaminases, Transferases, Enzyme, Evolution, Article synthèse, Homme, Appareil digestif pathologie, Foie pathologie
Mots-clés Pascal anglais : Viral hepatitis C, Viral disease, Infection, Hepatitis C virus, Flaviviridae, Virus, Asymptomatic, Incidence, Risk factor, Drug addiction, Diagnosis, Assay, RNA, Transaminases, Transferases, Enzyme, Evolution, Review, Human, Digestive diseases, Hepatic disease
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Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0515002
Code Inist : 002B05C02G. Création : 13/02/1998.