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  1. Birth characteristics, sibling patterns, and acute leukemia risk in childhood : a population-based cohort study.

    Article - En anglais


    The occurrence of acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML) during childhood may be influenced by factors operating in fetal life.

    Furthermore, childhood ALL has been suggested to be linked to patterns of infection during infancy.


    To explore these hypotheses and other associations, we studied the impact of sibling patterns (e.g., birth order) and birth characteristics (e.g., birth weight) on the risk of childhood ALL and AML.


    By linkage of records of population-based registries, a cohort of all children whose mothers were born in Denmark from April 1935 through March 1978 was established.

    Children who developed ALL or AML during the period from April 1968 through December 1992 were identified by linkage with the Danish Cancer Registry.

    Birth weights were obtained for children born during the period from January 1973 through December 1992 by linkage with the Medical Birth Registry.


    The cohort of approximately 2.0 million children was followed for the diagnosis of ALL or AML for 20.9 million person-years.

    A total of 704 cases of childhood ALL were identified.

    Among 0-4 year olds, the relative risks (RRs) of ALL for birth order positions 1,2,3, and 4+were 1.00 (reference), 0.85 (95% confidence interval [CI]=0.68-1.07), 0.91 (95% CI=0.66-1.25), and 0.57 (95% CI=0.30-1.06), respectively (P for trend=09).

    A decreasing trend was not observed among 5-14 year olds. (...)

    Mots-clés Pascal : Leucémie lymphoblastique, Leucémie myéloblastique, Facteur risque, Epidémiologie, Poids naissance, Rang naissance, Etude cohorte, Registre, Danemark, Europe, Enfant, Homme, Aigu, Hémopathie maligne, Lymphoprolifératif syndrome

    Mots-clés Pascal anglais : Acute lymphocytic leukemia, Acute myelocytic leukemia, Risk factor, Epidemiology, Birth weight, Birth order, Cohort study, Register, Denmark, Europe, Child, Human, Acute, Malignant hemopathy, Lymphoproliferative syndrome

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 97-0513879

    Code Inist : 002B19B. Création : 13/02/1998.