Relationship between lifetime ovulatory cycles and overexpression of mutant p53 in epithelial ovarian cancer.
Several lines of evidence have suggested a relationship between a woman's number of ovulatory cycles and the development of ovarian epithelial cancer.
Repair of the ovarian surface after ovulation requires cellular proliferation, and spontaneous mutations arising during the DNA synthesis that accompanies this proliferation may play a role in carcinogenesis.
We conducted a molecular epidemiologic study to test the hypothesis that a greater number of ovulatory cycles increases the risk of ovarian cancer by inducing proliferation-associated DNA damage.
In particular, we examined the association between the lifetime number of ovulatory cycles and mutation of the p53 tumor-suppressor gene (also known as TP53) in ovarian tumors.
Case-case and case-control analyses involving participants in the Cancer and Steroid Hormone study were used to examine the association between p53 gene mutation in ovarian tumors and the lifetime number of ovulatory cycles.
The women in our study were 20-54 years of age and included 197 case patients with invasive ovarian epithelial cancer and 3363 control subjects.
Mutation of the p53 gene was indicated by overexpression of p53 protein (i.e., cellular accumulation of mutant p53 protein) in paraffin-embedded ovarian cancer tissue blocks ; the mutant protein was detected by means of standard immunohistochemical techniques. (...)
Mots-clés Pascal : Carcinome, Ovaire, Facteur risque, Epidémiologie moléculaire, Cycle ovulatoire, Nombre, Mutation, Gène suppresseur tumeur, Gène TP53, Surexpression génique, Etude cas témoin, Homme, Etats Unis, Amérique du Nord, Amérique, Tumeur maligne, Appareil génital femelle pathologie, Ovaire pathologie
Mots-clés Pascal anglais : Carcinoma, Ovary, Risk factor, Molecular epidemiology, Ovulatory cycle, Number, Mutation, Tumor suppressor gene, TP53 Gene, Gene overexpression, Case control study, Human, United States, North America, America, Malignant tumor, Female genital diseases, Ovarian diseases
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0513878
Code Inist : 002B20C02. Création : 13/02/1998.