Familial clustering has been observed for cancers that occur at specific sites.
Most findings, which leave little doubt about the involvement of a heritable (i.e., genetic) component in the development of some cancers, are based on data from « cancer-prone » families or interviews with subjects who have cancer.
The study of twins should be of value in cancer epidemiology because twins either are genetically identical or share half of their segregating genes.
We linked the Swedish Twin Registry to the Swedish Cancer Registry, thereby identifying cases of cancer diagnosed from 1959 through 1992 in twins born in the period from 1886 through 1958, to assess the importance of both genetic and nongenetic (i.e., environmental) familial factors in determining cancer risk.
Same-sex twin pairs with both individuals alive and living in Sweden in 1959-1961 or 1970-1972 were identified in the old cohort (born from 1886 through 1925) or the young cohort (born from 1926 through 1958), respectively, of the Swedish Twin Registry ; pairs for whom zygosity (i.e., the number of eggs that gave rise to the twins) could be determined were considered further.
The association of cancer with combined genetic and nongenetic familial factors was tested by comparing all twin pairs (regardless of zygosity) in which at least one member of the pair had been diagnosed with cancer at one of several specific sites with pairs in which neither twin had that cancer. (...)
Mots-clés Pascal : Tumeur maligne, Facteur risque, Zygotie, Jumeau, Déterminisme génétique, Registre, Epidémiologie, Suède, Europe, Homme
Mots-clés Pascal anglais : Malignant tumor, Risk factor, Zygozity, Twin, Genetic inheritance, Register, Epidemiology, Sweden, Europe, Human
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0512601
Code Inist : 002B04B. Création : 13/02/1998.