Genomic variation of human papillomavirus type 16 and risk for high grade cervical intraepithelial neoplasia.
Epidemiologic studies have demonstrated strong and consistent associations between the detection of human papillomavirus (HPV) type 16 DNA and the risk of cervical intraepithelial neoplasia (CIN) and cervical cancer.
However, HPV16 is also the most common type of HPV in the normal population, and only a minority of women with HPV16 infection develop cervical cancer.
Studies of genomic heterogeneity in HPV16 have demonstrated the presence of multiple variant forms in all human populations examined to date.
It is conceivable that the natural variants of HPV16 in a given population may not have the same biologic behavior.
This study was designed to determine the association between natural variants of HPV16 and the risk of biopsy-confirmed CIN 2 or 3, the most important precancerous lesions of the uterine cervix.
Prospective studies were conducted among 1) women attending a university and 2) women presenting to a sexually transmitted disease clinic.
Subjects were eligible for inclusion in this investigation if the initial cytologic findings did not reveal CIN 2-3 and HPV16 DNA was detected by means of a polymerase chain reaction (PCR) - based method in one or more cervical or vul-vovaginal samples.
Eligible subjects were followed every 4 months with cervical Pap smears and colposcopic examinations.
Women were referred for biopsy if cytology or colposcopy suggested CIN 2-3. (...)
Mots-clés Pascal : Carcinome, Col utérus, Cancer in situ, Dysplasie, Lésion précancéreuse, Facteur risque, Virose, Infection, Papillomavirus humain 16, Papillomavirus, Papovaviridae, Virus, Variant génétique, Epidémiologie, Haute malignité, Etats Unis, Amérique du Nord, Amérique, Homme, Appareil génital femelle pathologie, Col utérus pathologie, Tumeur maligne
Mots-clés Pascal anglais : Carcinoma, Uterine cervix, Carcinoma in situ, Dysplasia, Premalignant lesion, Risk factor, Viral disease, Infection, Human papillomavirus 16, Papillomavirus, Papovaviridae, Virus, Genetic variant, Epidemiology, High malignancy, United States, North America, America, Human, Female genital diseases, Uterine cervix diseases, Malignant tumor
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0512600
Code Inist : 002B20C02. Création : 13/02/1998.