Benzene and the dose-related incidence of hematologic neoplasms in China.
Benzene is a widely distributed environmental contaminant known to cause leukemia, particularly acute nonlymphocytic leukemia, and perhaps other hematologic neoplasms and disorders.
Few epidemiologic studies, however, have been able to address relationships between the extent of benzene exposure and the level of risk.
A large cohort study was carried out in China to evaluate the risks of developing specific hematologic neoplasms and selected related disorders in relationship to quantitative estimates of occupational benzene exposure.
A cohort of 74828 benzene-exposed and 35805 unexposed workers employed from 1972 through 1987 in 12 cities in China was identified and followed to determine the incidence of hematologic neoplasms and related disorders.
Estimates of benzene exposure were derived from work histories and available historic benzene measurements.
Existing pathologic material and supporting medical records were reviewed to establish diagnoses of disease.
Relative risks (RRs) (i.e., ratios of incidence rates for specific hematologic neoplasms and related disorders in the benzene-exposed group to incidence rates in the unexposed group) were determined by use of Poisson regression analysis, with stratification by age and sex.
For workers historically exposed to benzene at average levels of less than 10 parts per million (ppm), the RR for all hematologic neoplasms combined was 2.2 (95% confidence interval [CI]=1.1-4. (...)
Mots-clés Pascal : Hémopathie maligne, Facteur risque, Epidémiologie, Exposition professionnelle, Benzène, Solvant organique, Composé organique, Toxicité, Relation dose réponse, Chine, Asie, Etude cohorte, Incidence, Homme, Médecine travail
Mots-clés Pascal anglais : Malignant hemopathy, Risk factor, Epidemiology, Occupational exposure, Benzene, Organic solvent, Organic compounds, Toxicity, Dose activity relation, China, Asia, Cohort study, Incidence, Human, Occupational medicine
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0512584
Code Inist : 002B03L06. Création : 13/02/1998.