There are few previous epidemiologic studies of gallbladder cancer, a rare but nearly always lethal gastrointestinal cancer with a demonstrated greater frequency in adult women and older subjects of both sexes, and also in the members of populations throughout central and eastern Europe and certain racial groups such as native American Indians.
Unfortunately, the prospects for the prevention of this form of cancer are poor.
Our purpose in conducting this study was to investigate possible new risk factors for gallbladder cancer and to strengthen our understanding of established causal agents that may be involved in this disease.
A large, collaborative, multicenter, case-control study of cancer of the gallbladder was conducted in five centers located in Australia (Adelaide), Canada (Montreal and Toronto), The Netherlands (Utrecht), and Poland (Opole) from January 1983 through July 1988.
Case subjects with gallbladder cancer were accrued by the centers from hospital pathology records and from reports to regional cancer registries.
Cancer diagnosis was confirmed by either biopsy, cholecystectomy, or at the time of autopsy.
Control subjects were randomly assigned at each center from the population.
The pooled analysis included 196 case subjects and 1515 control subjects (who did not report previous cholecystectomy).
Ninety-eight percent of the subjects were white. (...)
Mots-clés Pascal : Tumeur maligne, Vésicule biliaire, Facteur risque, Lithiase, Epidémiologie, Etude cas témoin, Australie, Océanie, Canada, Amérique du Nord, Amérique, Pays Bas, Europe, Pologne, Etude multicentrique, Homme, Voie biliaire pathologie, Appareil digestif pathologie
Mots-clés Pascal anglais : Malignant tumor, Gallbladder, Risk factor, Lithiasis, Epidemiology, Case control study, Australia, Oceania, Canada, North America, America, Netherlands, Europe, Poland, Multicenter study, Human, Biliary tract disease, Digestive diseases
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0512579
Code Inist : 002B13C01. Création : 13/02/1998.