Rheumatoid arthritis and the risk of malignancy.
To determine the relative risks of malignancy and of site-specific malignancies in patients with rheumatoid arthritis (RA).
In a prospective cohort study, 862 patients with RA (96% white) were enrolled from 1966 to 1974 and were followed up for up to 35 years (mean 17.4 years) at the University of Saskatchewan Rheumatic Disease Unit.
All diagnoses of cancer were cross-referenced with the Provincial Cancer Registry.
Expected cancer incidence rates were determined based on province of Saskatchewan population statistics matched to each study patient for age, sex, and calendar year.
Standardized incidence ratios (SIRs) of the observed-to-expected cancer incidence and 95% confidence intervals (95% CI) were then calculated.
A total of 136 cases of cancer were observed compared with 168 expected (SIR 0.80, P=0.011 [95% CI 0.67-0.95]). The relative risk of colorectal malignancy was significantly reduced in the RA study population (SIR 0.52, P=0.037 [95% CI 0.25-0.96]). A significant excess of leukemia was found (SIR 2.47, P=0.026 [95% CI 1.12-4.69]), whereas the incidence rates for Hodgkin's disease and non-Hodgkin's lymphoma and all other site-specific malignancies were not found to be significantly different from general population rates.
In our cohort of RA patients, colorectal cancer was detected in only half the expected number of patients. (...)
Mots-clés Pascal : Polyarthrite rhumatoïde, Homme, Association, Tumeur maligne, Facteur risque, Localisation, Epidémiologie, Incidence, Etude longitudinale, Long terme, Chronique, Système ostéoarticulaire pathologie, Rhumatisme inflammatoire, Immunopathologie, Maladie autoimmune
Mots-clés Pascal anglais : Rheumatoid arthritis, Human, Association, Malignant tumor, Risk factor, Localization, Epidemiology, Incidence, Follow up study, Long term, Chronic, Diseases of the osteoarticular system, Inflammatory joint disease, Immunopathology, Autoimmune disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0512493
Code Inist : 002B15D. Création : 13/02/1998.