Winter research and practice forum of the American College of Clinical Pharmacy. Monterey, California (USA), 1996/02/11.
We compared total costs and adherence to the regimen of older versus newer angiotensin-converting enzyme (ACE) inhibitors for the treatment of elderly patients with hypertension.
A computer search using the data base of a health care insurer identified 6176 subjects age 65 years or older who had ICD-9 coding for hypertension only and had a new prescription for an ACE inhibitor dispensed between April 1,1992, and January 31,1993.
Subjects receiving concurrent antihypertensive drugs were included.
Total cost of therapy included acquisition costs for the ACE inhibitors and concurrent antihypertensive agents, and nondrug costs.
Other costs were laboratory tests, hospitalization, and clinic visits associated with monitoring outcomes of antihypertensive therapy.
Total median cost per month was greater for older than for newer agents, $59.82 versus $53.09 (p<0.0009).
The mean percentage of patients complying with therapy as determined by refill data was greater with newer than with older agents, 66% versus 58% (p<0.0001).
Based on our results, newer ACE inhibitors should be first-line antihypertensive therapy in elderly patients.
They also should be considered for elderly patients who are unresponsive to older ACE inhibitors.
Mots-clés Pascal : Inhibiteur angiotensin converting enzyme, Protocole thérapeutique, Antihypertenseur, Etude comparative, Hypertension artérielle, Homme, Vieillard, Analyse coût, Analyse avantage coût, Recherche développement, Observance thérapeutique, Assistance ordinateur, Base donnée, Assurance maladie, Coût global, Economie santé, Analyse économique, Recommandation, Appareil circulatoire pathologie
Mots-clés Pascal anglais : ACE inhibitor, Therapeutic protocol, Antihypertensive agent, Comparative study, Hypertension, Human, Elderly, Cost analysis, Cost benefit analysis, Research and development, Treatment compliance, Computer aid, Database, Health insurance, Life cycle cost, Health economy, Economic analysis, Recommendation, Cardiovascular disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0512076
Code Inist : 002B02F05. Création : 13/02/1998.