Prospective seroepidemiologic study of human papillomavirus infection as a risk factor for invasive cervical cancer.
Major risk factors for invasive cervical cancer include infection with human papillomavirus (HPV), infection with other sexually transmitted pathogens (e.g., Chla-mydia trachomatis), and smoking.
Since exposures to these risk factors can be related, the contribution of any single factor to cervical carcinogenesis has been difficult to assess.
We conducted a prospective study to define the role of HPV infection in cervical carcinogenesis, with invasive cancer as an end point.
A nested case-control study within a joint cohort of 700000 Nordic subjects was performed.
The 182 women who developed invasive cervical cancer during a mean follow-up of 5 years were matched with 538 control women on the basis of age and time of enrollment.
Serum samples taken at enrollment were analyzed for evidence of tobacco use (i.e., cotinine levels) ; for antibodies against HPV types 16,18, and 33 ; and for antibodies against C. trachomatis.
Relative risks (RRs) were estimated by use of conditional logistic regression.
Presence of antibodies against HPV in serum (seropositivity) was associated with an increased risk of cervical cancer, and adjustment for smoking and for C. trachomatis seropositivity did not affect this finding (RR=2.4 ; 95% confidence interval [CI]=1.6-3.7).
HPV16 seropositivity was associated primarily with an increased risk of squamous cell carcinoma (RR=3.2 ; 95% CI=1.7-6.2). (...)
Mots-clés Pascal : Tumeur maligne, Col utérus, Facteur risque, Epidémiologie, Virose, Infection, Papillomavirus humain, Papillomavirus, Papovaviridae, Virus, Sérologie, Etude cas témoin, Finlande, Europe, Norvège, Suède, Homme, Appareil génital femelle pathologie, Col utérus pathologie
Mots-clés Pascal anglais : Malignant tumor, Uterine cervix, Risk factor, Epidemiology, Viral disease, Infection, Human papillomavirus, Papillomavirus, Papovaviridae, Virus, Serology, Case control study, Finland, Europe, Norway, Sweden, Human, Female genital diseases, Uterine cervix diseases
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0510961
Code Inist : 002B20C02. Création : 13/02/1998.