Incidence rates for adenocarcinomas of the esophagus and gastric cardia have risen steeply over the last few decades.
To determine risk factors for these tumors, we conducted a multicenter, population-based, case-control study.
The study included 554 subjects newly diagnosed with esophageal or gastric cardia adenocarcinomas, 589 subjects newly diagnosed with esophageal squamous cell carcinoma or other gastric adenocarcinomas, and 695 control subjects.
Estimates of risk (odds ratios [ORs] and corresponding 95% confidence intervals [CIs]) were calculated for the four tumor types separately and for esophageal and gastric cardia adenocarcinomas combined.
Risk of esophageal and gastric cardia adenocarcinomas combined was increased among current cigarette smokers (OR=2.4 ; 95%=1.7-3.4), with little reduction observed until 30 years after smoking cessation ; this risk rose with increasing intensity and duration of smoking.
Risk of these tumors was not related to beer (OR=0.8 ; 95% CI=0.6-1.1) or liquor (OR=1.1 ; 95% CI=0.8-1.4) consumption, but it was reduced for drinking wine (OR=0.6 ; 95% CI=0.5-0.8).
Similar ORs were obtained for the development of noncardia gastric adenocarcinomas in relation to tobacco and alcohol use, but higher ORs were obtained for the development of esophageal squamous cell carcinomas.
For all four tumor types, risks were higher among those with low income or education. (...)
Mots-clés Pascal : Adénocarcinome, Estomac, Cardia, Oesophage, Facteur risque, Epidémiologie, Alcoolisme, Statut socioéconomique, Tabagisme, Etude cas témoin, Etude multicentrique, Etats Unis, Amérique du Nord, Amérique, Homme, Tumeur maligne, Appareil digestif pathologie, Estomac pathologie, Oesophage pathologie
Mots-clés Pascal anglais : Adenocarcinoma, Stomach, Cardia, Esophagus, Risk factor, Epidemiology, Alcoholism, Socioeconomic status, Tobacco smoking, Case control study, Multicenter study, United States, North America, America, Human, Malignant tumor, Digestive diseases, Gastric disease, Esophageal disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0510959
Code Inist : 002B13A01. Création : 13/02/1998.