CYP2E1 Genetic polymorphisms and risk of nasopharyngeal carcinoma in Taiwan.
Nasopharyngeal carcinoma occurs disproportionately among individuals of Chinese descent.
The cytochrome P450 2E1 enzyme (CYP2E1) is known to activate nitrosamines and other carcinogens that are possibly involved in the development of this disease.
Certain alleles of the CYP2E1 gene are thought to be more highly expressed than others, and their distribution varies between Asian and Caucasian populations.
We conducted a case-control study to investigate whether such variations affect the risk of developing nasopharyngeal cancer.
Three hundred sixty-four patients with nasopharyngeal carcinoma (96% of 378 eligible patients) and 320 control subjects (86% of 374 eligible subjects) were studied.
A risk factor questionnaire was administered to participants to assess factors postulated to be linked to nasopharyngeal carcinoma.
Peripheral blood was obtained from all subjects and DNA was purified from nucleated cells.
A polymerase chain reaction-based restriction fragment length polymorphism assay that used the restriction enzymes Rsa I and Dra I was used to detect wild-type and variant forms of the CYP2E1 gene.
Individuals homozygous for an allele of the CYP2E1 gene that is detected by Rsa I digestion (c2 allele) were found to have an increased risk of nasopharyngeal carcinoma (relative risk [RR]=2.6 ; 95% confidence interval [CI]=1.2-5.7) ; this effect was limited to non-smokers. (...)
Mots-clés Pascal : Carcinome, Nasopharynx, Cytochrome P450, Isozyme, Variabilité génétique, Facteur risque, Epidémiologie, Taiwan, Asie, Génotype, Homme, ORL pathologie, Pharynx pathologie, Tumeur maligne
Mots-clés Pascal anglais : Carcinoma, Nasopharynx, Cytochrome P450, Isozyme, Genetic variability, Risk factor, Epidemiology, Taiwan, Asia, Genotype, Human, ENT disease, Pharynx disease, Malignant tumor
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0510912
Code Inist : 002B10B01. Création : 13/02/1998.