Paternal cigarette smoking and the risk of childhood cancer among offspring of nonsmoking mothers.
Cigarette smoking has been shown to increase oxidative DNA damage in human sperm cells.
Assessment of the role of cigarette smoking in the etiology of childhood cancer has focused primarily on the effect of maternal smoking.
Similar studies in relation to paternal smoking, however, have been inconclusive.
Few studies have evaluated the effect of paternal smoking in the preconception period, and most of these could not disentangle the effects of paternal from maternal smoking.
We investigated the relationship of paternal smoking, particularly in the preconception period, with childhood cancer among offspring of the nonsmoking mothers.
We conducted a population-based, case-control study in Shanghai, People's Republic of China, where the prevalence of smoking is high among men but extremely low among women.
The study included 642 childhood cancer case patients (<15 years of age) and their individually matched control subjects.
Information concerning parental smoking, alcohol drinking, and other exposures of the index child was obtained by direct interview of both parents of the study subjects.
Odds ratios (ORs), derived from conditional logistic regression models, were used to measure the association between paternal smoking and risk of childhood cancers.
Results and Conclusions
Paternal preconception smoking was related to a significantly elevated risk of childhood cancers, particularly acute leukemia and lymphoma. (...)
Mots-clés Pascal : Tumeur maligne, Hémopathie maligne, Facteur risque, Tabagisme, Père, Epidémiologie, Chine, Asie, Etude cas témoin, Enfant, Homme
Mots-clés Pascal anglais : Malignant tumor, Malignant hemopathy, Risk factor, Tobacco smoking, Father, Epidemiology, China, Asia, Case control study, Child, Human
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0510828
Code Inist : 002B04B. Création : 13/02/1998.