Association of Prostate cancer risk with genetic polymorphisms in vitamin D receptor and androgen receptor.
Prostate cancer is an increasingly common disease for which there are few well-established risk factors.
Family history data suggest a genetic component ; however, the majority of prostate cancer cases cannot be explained by a single-gene model.
Prostate cell division is influenced by two steroid hormones, testosterone and vitamin D, the action of each being mediated by its respective receptor.
The genes for the two receptors are candidates in a multigenic model for prostate cancer susceptibility.
We examined genetic polymorphisms in two steroid receptors, the androgen receptor (AR) and the vitamin D receptor (VDR), in a case-control pilot study of prostate cancer.
Fifty-seven non-Hispanic white case patients with prostate cancer and 169 non-Hispanic white control subjects were genotyped for a previously described microsatel-lite (CAG repeats) in the AR gene and for a newly discovered poly-A micro-satellite in the 3'-untranslated region (3'UTR) of the VDR gene.
To compare genotypes with respect to prostate cancer risk, we estimated odds ratios (ORs) by using logistic regression.
ORs were also estimated separately for advanced and localized cases of disease.
All P values resulted from two-sided tests.
Both the AR and the VDR polymorphisms were associated, individually and after mutual adjustment, with prostate cancer.
Adjusted ORs (95% confidence intervals [CIs]) for prostate cancer were 2.10 (95% CI=1.11-3. (...)
Mots-clés Pascal : Tumeur maligne, Prostate, Facteur risque, Androgène, Récepteur biologique, Gène, Vitamine D, Variabilité génétique, Epidémiologie, Etude cas témoin, Etats Unis, Amérique du Nord, Amérique, Homme, Appareil génital mâle pathologie, Appareil urinaire pathologie, Prostate pathologie, Hormone stéroïde sexuelle
Mots-clés Pascal anglais : Malignant tumor, Prostate, Risk factor, Androgen, Biological receptor, Gene, Vitamin D, Genetic variability, Epidemiology, Case control study, United States, North America, America, Human, Male genital diseases, Urinary system disease, Prostate disease, Sex steroid hormone
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0509363
Code Inist : 002B14D02. Création : 13/02/1998.