A serological survey to determine the immunity to diphtheria in the Flemish population was conducted according to the recommendations of the World Health Organization.
Immunity to diphtheria was determined on a randomised, stratified sample (1679 serum samples) from an existing serum bank (4058 serum samples) representative of the Flemish population.
All age groups between 0 and 100 years were included.
A tissue (vero cell) culture toxin neutralisation assay was used to measure serum diph-theria antitoxin concentrations.
The results showed that 43% of the Flemish population was protected against diphtheria (antitoxin titre, = 0.1 IU/ml), while 32% was susceptible (antitoxin titre,<0.01 lU/ml) ; for 25%, protection was of limited duration (antitoxin titre, =0.01 lU/ml and<0.1 lU/ml).
The proportion of susceptible subjects showed a significant age-related increase, with the highest values in the 35 to 44 and 45 to 54 age groups (57.9% and 55.5%, respectively).
These results emphasise the need for booster immunization of adults.
Mots-clés Pascal : Diphtérie, Bactériose, Infection, Evaluation, Immunité, Belgique, Europe, Homme, Prévalence, Anticorps, Epidémiologie, Indication, Rappel vaccination, Adulte
Mots-clés Pascal anglais : Diphtheria, Bacteriosis, Infection, Evaluation, Immunity, Belgium, Europe, Human, Prevalence, Antibody, Epidemiology, Indication, Booster vaccination, Adult
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0506901
Code Inist : 002B05B02B. Création : 13/02/1998.