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  1. Three methods of opioid detoxification in a primary care setting : A randomized trial.

    Article - En anglais

    Background 

    Opioid detoxification in a primary care setting followed by ongoing substance abuse treatment may be appropriate for selected opioid-dependent patients.

    Objective 

    To compare three pharmacologic protocols for opioid detoxification in a primary care setting.

    Design 

    Randomized, double-blind clinical trial with random assignment to treatment protocols.

    Setting 

    A free-standing primary care clinic affiliated with drug treatment programs.

    Patients 

    162 heroin-dependent patients.

    Interventions 

    Three detoxification protocols : clonidine, combined clonidine and naltrexone, and buprenorphine.

    Measurements 

    Successful detoxification (that is, when study participants received a full opioid-blocking dose [50 mg] of naltrexone), treatment retention (8 days), and withdrawal symptoms.

    Results 

    Overall, 65% of participants (36 of 55) who received clonidine, 81% (44 of 54) who received combined clonidine and naltrexone, and 81% (43 of 53) who received buprenorphine were successfully detoxified.

    Retention did not differ significantly across the groups : 65% of participants (36 of 55) who received clonidine, 54% (29 of 54) who received combined clonidine and naltrexone, and 60% (32 of 53) who received buprenorphine.

    Participants who received buprenorphine had a significantly lower mean withdrawal symptom score than those who received clonidine or combined clonidine and naltrexone. (...)

    Mots-clés Pascal : Toxicomanie, Randomisation, Protocole thérapeutique, Détoxication, Pharmacocinétique, Etude double insu, Clonidine, Naltrexone, Etude comparative, Buprénorphine, Evaluation, Centre santé, Homme, Opiacés, Système nerveux pathologie, Psychopathologie, Toxicologie, Education santé, Imidazoline dérivé

    Mots-clés Pascal anglais : Drug addiction, Randomization, Therapeutic protocol, Detoxication, Pharmacokinetics, Double blind study, Clonidine, Naltrexone, Comparative study, Buprenorphine, Evaluation, Health center, Human, Opiates, Nervous system diseases, Psychopathology, Toxicology, Health education

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 97-0506810

    Code Inist : 002B03D. Création : 13/02/1998.