Three methods of opioid detoxification in a primary care setting : A randomized trial.
Opioid detoxification in a primary care setting followed by ongoing substance abuse treatment may be appropriate for selected opioid-dependent patients.
To compare three pharmacologic protocols for opioid detoxification in a primary care setting.
Randomized, double-blind clinical trial with random assignment to treatment protocols.
A free-standing primary care clinic affiliated with drug treatment programs.
162 heroin-dependent patients.
Three detoxification protocols : clonidine, combined clonidine and naltrexone, and buprenorphine.
Successful detoxification (that is, when study participants received a full opioid-blocking dose [50 mg] of naltrexone), treatment retention (8 days), and withdrawal symptoms.
Overall, 65% of participants (36 of 55) who received clonidine, 81% (44 of 54) who received combined clonidine and naltrexone, and 81% (43 of 53) who received buprenorphine were successfully detoxified.
Retention did not differ significantly across the groups : 65% of participants (36 of 55) who received clonidine, 54% (29 of 54) who received combined clonidine and naltrexone, and 60% (32 of 53) who received buprenorphine.
Participants who received buprenorphine had a significantly lower mean withdrawal symptom score than those who received clonidine or combined clonidine and naltrexone. (...)
Mots-clés Pascal : Toxicomanie, Randomisation, Protocole thérapeutique, Détoxication, Pharmacocinétique, Etude double insu, Clonidine, Naltrexone, Etude comparative, Buprénorphine, Evaluation, Centre santé, Homme, Opiacés, Système nerveux pathologie, Psychopathologie, Toxicologie, Education santé, Imidazoline dérivé
Mots-clés Pascal anglais : Drug addiction, Randomization, Therapeutic protocol, Detoxication, Pharmacokinetics, Double blind study, Clonidine, Naltrexone, Comparative study, Buprenorphine, Evaluation, Health center, Human, Opiates, Nervous system diseases, Psychopathology, Toxicology, Health education
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0506810
Code Inist : 002B03D. Création : 13/02/1998.