Screening patients with celiac disease for primary biliary cirrhosis and vice versa.
An association between celiac disease and primary biliary cirrhosis has been reported in a few cases, mainly as individual case reports.
To screen adult patients with celiac disease for primary biliary cirrhosis and patients with primary biliary cirrhosis for intestinal celiac involvement.
The celiac group consisted of 336 adults (218 women and 118 men ; mean age, 36 yr ; range 18-74 yr) with celiac disease diagnosed by serological and histological tests, 38 with newly diagnosed celiac disease and 298 with previously diagnosed celiac disease who were consuming a gluten-free diet.
The mean follow-up period was 6 yr (range, 1-16 yr).
Liver function parameters and autoantibody levels were determined, and, when indicated, histological tests were performed.
The biliary cirrhosis group consisted of 65 subjects (58 women and seven men) (mean age, 59 yr ; range, 35-67 yr) with primary biliary cirrhosis diagnosed 1-17 years previously (mean, 7 yr) on the basis of the usual biochemical, serological, and histological criteria.
Antigliadin and antiendomysium antibody levels were determined, and two biopsy specimens from the distal duodenum obtained during endoscopy were evaluated.
In patients with celiac disease, impairment of liver function was frequently found at diagnosis (16 of 38, or 44%), but primary biliary cirrhosis was diagnosed in only one case. (...)
Mots-clés Pascal : Coeliaque maladie, Dépistage, Association morbide, Cirrhose biliaire, Primitif, Prévalence, Résultat, Homme, Appareil digestif pathologie, Intestin pathologie, Malabsorption intestinale, Immunopathologie, Foie pathologie, Voie biliaire pathologie, Maladie autoimmune
Mots-clés Pascal anglais : Coeliac disease, Medical screening, Concomitant disease, Biliary cirrhosis, Primitive, Prevalence, Result, Human, Digestive diseases, Intestinal disease, Intestinal malabsorption, Immunopathology, Hepatic disease, Biliary tract disease, Autoimmune disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0506694
Code Inist : 002B13C03. Création : 13/02/1998.